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Chemotherapy

Used in the following circumstances:

·   To cure some tumor variants

·   To alleviate symptoms caused by the disease

 

Contraindications: Chemotherapy drugs are not recommended or forbidden in the following situations: 

·   If methods and techniques to evaluate animal response to treatments are not adequate.

·   If, although reducing tumor size, therapy is incapable of extending animal's life.

·   If it is not probable that the patient will live long enough to feel the benefits of the treatment (i.e.: weak animals)

·   If the animal has a low growth rate tumor, incurable (i.e. some skull osteosarcomas)

 
 

Neoplasia sensitivity to Chemotherapy

Curable

·   Transmissible venereal tumor (TVT)

·   Some Lymphomas

 

Improvement in survival quality 

·   Lymphomas

·   Leukemia

·   Breast cancer

·   Osteosarcomas

·   Mastocytomas

·   Bladder carcinoma

 

Palliative

·   Thyroid Carcinoma

 

Ineffective or Occasional response

·   Melanomas

·   Sarcomas

·   Hemangiosarcomas       

·   Squamous cell carcinoma

·   Hepatic neoplasia

·   Lung cancer

·   Pancreatic cancer

 

 Adjuvant chemotherapy 

This therapy is complementary with surgery or radiotherapy. It is applied to animals with no evidence of  residual disease (tumor cells that cannot be detected by standard analysis), but with high risk of relapse (no matter the success of previous treatment or surgery).

The use of adjuvant chemotherapy is justified by high levels of relapses seen after surgery in cases where the tumor is thought to be confined, incapacity to identify curable patients before surgery and failure of treatments.

Disadvantages of these methods are side-effects and eventual risks in short or long term. So far, the only variants that have shown positive response to adjuvant chemotherapies are breast cancer, osteosarcoma, TVT, bladder carcinoma and some mastocytomas.

 

Treatment monitoring 

Administration of chemotherapy drugs needs precise knowledge from the professional concerning disease progression, toxicity of previous treatments and estimated time for the appearance of new toxicity effects. Dated evolution tables, doses, responses, side-effects and lab values recordings are mandatory.